New Radiesse Research Highlights Deeper Extracellular Matrix Regeneration

New clinical research from Merz Aesthetics suggests that Radiesse (calcium hydroxylapatite) may stimulate broader skin regeneration than previously understood, including improvements in deeper structural damage caused by sun exposure.

Published in the Journal of Cosmetic Dermatology, the six-month, placebo-controlled human biomarker study compared diluted and undiluted formulations of Radiesse against saline placebo, in one of the most comprehensive human-based evaluations of ECM regeneration in aesthetic medicine.

“While previous research has shown that biostimulation with RADIESSE has a positive impact on both collagen and elastin production, the latest evidence published today demonstrates it also supports a broader remodeling process – including notable improvements to sun damaged skin,” said Owen Sunga, M.D., Executive Vice President, Head of Global Medical Affairs.

The results showed significant increases across several key proteins associated with skin quality and structure. Collagen levels increased by as much as 23 times compared with placebo, while elastin levels rose by approximately 96%. Other ECM components linked to hydration and tissue organization, including decorin and versican, also showed substantial gains.

Beyond protein support, the study also found measurable improvements in solar elastosis, a form of deep structural sun damage that contributes to wrinkles, laxity, and crepey skin. Solar elastosis occurs deep within the dermis and has historically been difficult to treat with injectables designed primarily for volume restoration. At sites treated with Radiesse, researched noted significant improvements in elastosis at both three and six months post-injection, suggesting the injectable affects multiple tissue layers.

“Sun damage is one of the most common concerns we see in patients, and the damage itself extends far beyond what’s visible on the surface,” said Gabriela Casabona, M.D., study author and renowned dermatologist, in a statement announcing the results. “Finding that RADIESSE plays a role in addressing ultrasonographic features of solar elastosis adds an important dimension to how we think about this treatment.”